Constipation

Is colonic irrigation a suitable method for recovery from stress?

People today live in unsuitable conditions. In addition to a sedentary lifestyle, many of us often experience enormous and long-lasting stress. Emotional states have severe effects on the body’s health. Long periods of stress can lead to intestinal dysfunction and affect the entire gastrointestinal tract. Colonic irrigation helps prevent issues like chronic constipation. Our clinic offers colon hydrotherapy treatments using high-quality equipment under the supervision of experienced specialists.

What is the effect that the CRF system has on the intestines?

Corticotropin-releasing factor (CRF) signalling systems include CRF and structurally related peritonic urocortin (Ucn). CRF binds with high and moderate affinities to CRF-1 and CRF-2 receptors, respectively. At the same time, Ucn1 is a high-affinity agonist in both receptors, and Ucn2 and Ucn3 are selective agonists of CRF-2. Researchers have identified CRF systems in the brain and colon at the gene and protein levels.

Experimental studies have shown that activating the CRF-1 pathway in the brain or colon allows recovery from diarrhoea and irritable bowel syndrome (IBS), primarily by stimulating colon motility, activating mast cells and serotonin, and reducing defecation and watery diarrhoea, as well as visceral hyperalgesia. In contrast, selective CRF-1 antagonists or CRF-1 / CRF-2 antagonists abrogated or decreased

• exogenous CRF,
• stress-induced stimulation of colon motility,
• defecation,
• diarrhoea,
• activation of the mast cell colon,
• Visceral hyperalgesia for colorectal stretching.

In contrast, CRF-2 signalling in the colon moistened CRF, mediated by stimulation of the colon’s motor function and visceral hyperalgesia.

Intestinal purification can significantly help with constipation after stressful experiences.

The data provide a conceptual basis for the continuous activation of the CRF-1 system at central and peripheral sites. And that may be one of the leading causes of IBS diarrhoea symptoms. However, targeting these mechanisms with CRF-1 antagonists provided a new and appropriate therapeutic approach. Unfortunately, nobody has yet translated these prospective preclinical data into the therapeutic use of CRF-1 antagonists. Whether existing or newly developed CRF-1 antagonists have therapeutic benefits for stress-sensitive diseases, such as IBS, remains to be seen.

Colonic irrigation can restore the natural microflora population, which decreases under stress. Also, the muscles of the large intestine return to their original shape and gain tone. As a result, the patient’s overall health improves, and the function of their digestive system also improves.