People today live in unsuitable conditions. In addition to the sedentary lifestyle, many of us often experience enormous long-lasting stress. Emotional states have severe effects on the body’s health. Long periods of stress could lead to the intestine and entire gastrointestinal tract dysfunction. Colonic irrigation allows the prevention of such issues as chronic constipation. Our clinic offers colon hydrotherapy treatments using high-quality equipment under the supervision of experienced specialists.
Corticotropin-releasing factor (CRF) signalling systems include CRF and structurally related peritonic urocortin (Ucn.); CRF binds to high and moderate affinities for CRF-1 and CRF-2 receptors, respectively. At the same time, Ucn1 is a high-affinity agonist in both receptors, and Ucn2 and Ucn3 are selective agonists of CRF-2. Researchers have identified CRF systems in the brain and colon at the gene and protein levels.
Experimental studies have established that activating the CRF-1 way in the brain or colon allows recovery from diarrhoea and predominantly irritable bowel syndrome (stimulation of colon motility, activation of mast cells and serotonin, defecation / watery diarrhoea and visceral hyperalgesia). In contrast, selective CRF-1 antagonists or CRF-1 / CRF-2 antagonists abrogated or decreased
In contrast, CRF-2 signalling in the colon moistened CRF with mediated stimulation of the motor function of the colon and visceral hyperalgesia.
The data provide a conceptual basis for the continuous activation of the CRF-1 system at central and peripheral sites. And that may be one of the leading causes of IBS diarrhoea symptoms. However, targeting these mechanisms by CRF-1 antagonists provided an appropriate new therapeutic place. Unfortunately, nobody has yet translated these prospective preclinical data into the therapeutic use of CRF-1 antagonists. Whether existing or newly developed CRF-1 antagonists have therapeutic benefits for stress-sensitive diseases, including IBS, they are still under development for some patients.
Colonic irrigation can restore the natural microflora population, which decreases under stress. Also, the muscles of the large intestine return to their original form, acquiring a tone. As a result, the general state of health of the patient improves. Likewise, the functionality of the digestive system improves too.