People today live in unsuitable conditions. In addition to the sedentary lifestyle, many of us often experience enormous long-lasting stress. Emotional states have severe effects on the body’s health. Long periods of stress could lead to the dysfunction of the intestine and the entire gastrointestinal tract. Colonic irrigation allows preventing such issues as chronic constipation. Our clinic offers colon hydrotherapy treatments with the use of high-quality equipment under the supervision of experienced specialists.
Corticotropin-releasing factor (CRF) signalling systems include CRF and structurally related peritonic urocortin (Ucn.), CRF binds to high and moderate affinities for CRF-1 and CRF-2 receptors, respectively, while Ucn1 is a high-affinity agonist in both receptors, and Ucn2 and Ucn3 are selective agonists of CRF-2. CRF systems are expressed in the brain and the large intestine at the gene and protein level.
Experimental studies have established that activating the CRF-1 way in the brain or colon allows for the recovery from diarrhoea and predominantly irritable bowel syndrome (stimulation of colon motility, activation of mast cells and serotonin, defecation / watery diarrhoea and visceral hyperalgesia). In contrast, selective CRF-1 antagonists or CRF-1 / CRF-2 antagonists abrogated or decreased
In contrast, CRF-2 signalling in the colon moistened CRF with mediated stimulation of the motor function of the colon and visceral hyperalgesia.
The data provide a conceptual basis for the continuous activation of the CRF-1 system at central and/or peripheral sites. And that may be one of the leading causes of IBS diarrhoea symptoms. However, the targeting of these mechanisms by CRF-1 antagonists provided an appropriate new therapeutic place. Unfortunately, nobody has translated these prospective preclinical data into the therapeutic use of CRF-1 antagonists yet. Whether existing or newly developed CRF-1 antagonists have therapeutic benefits for stress-sensitive diseases, including IBS, they are still under development for a subset of patients.
Colonic irrigation can restore the natural microflora that was lost under the influence of stress. The muscles of the large intestine return to their original form, acquiring a tone. As a result, the general state of health of the patient improves. Likewise, the functionality of the digestive system improves too.