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Probiotic bacteria strain – Bacillus subtilis
Bacillus subtilis is a specific, clinically tested and patented strain of probiotic bacteria. Firstly, it improves natural defences. Secondly, it helps fight infection and external aggression. Also, these probiotic strains with solid resistance to acidity
- have anti-bacterial and anti-fungal effects;
- may reduce the growth of pathogenic bacteria.
Therefore, specially selected and studied for its immunostimulant properties, this strain is listed as not in the Collection Nationale française de cultures de microorganisms (CNCM). I-2745. Pre-clinical and clinical trials have shown that taking the Probiotic Bacillus subtilis significantly boosts immunity in older people. As a result, it protects them from winter infections in particular. Unlike some other strains, these high-quality probiotic bacteria are spore-forming. For instance, it creates cells that are particularly thermo-resistant, offering many advantages:
- increased efficacy in the intestines, precisely where microflora is, due to very high resistance during passage through the digestive tract;
- increased stability in the capsule at ambient temperatures (DRcaps™);
- in vitro and in vivo in pre-clinical tests and a clinical trial in France demonstrated the high survival rate in the GI tract and the ability to activate IgA-producing cells (immunoglobulin A is a crucial immunity antibody).
What do studies show about Bacillus Subtilis?
Pre-clinical and clinical trials have shown that taking Bacillus subtilis boosts immunity in older people and protects them from winter infections. This double-blind clinical trial involved 44 subjects aged 60 and over. They took 20mg of Bacillus Subtilis ten days per month for four months during winter.
Further, the results showed vast improvements. Firstly, there was a significant increase (vs. placebo) in IgA concentrations in the respiratory and intestinal mucosa (saliva and stools). Secondly, there was a considerable decrease (38%) in the number of days with infectious episodes, and the likelihood of reporting infectious incidents was reduced.
Because of these factors, we recommend using the probiotic bacteria Bacillus subtilis freely by adults. Especially older individuals whose immune systems are under particular stress may need a boost as winter approaches can take it. People can also take these bacteria with vitamins D3, C, and zinc. In short, all of those have recognised immunostimulant properties.
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Composition of probiotic Bacillus subtilis
| Daily dose: 1 capsule. Number of doses per pack: 60 | Amount per dose |
| LifeinU™ Bacillus subtilis CU1 | 60 mg (3.109CFU) |
|
Other ingredients Acacia gum, white rice bran. Probisis®, Lesaffre, France. |
Directions for use
Adults. Take one capsule a day. Keep refrigerated.
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Researchers initially found Bacillus subtilis and Bacillus licheniformis in the soil in Siberia's ecologically clean region. Then, they derived the new strains by modifying them with plasmid pBMB 105, which can produce interferon 2-alpha-leukocytes in humans.
Activities
Being a factor of nonspecific resistance of the body, it plays a controlling and regulatory role in maintaining homeostasis in the human body and has the following main activities:
- antiviral effect;
- suppresses the growth and development of intracellular infectious agents of a non-viral nature (chlamydia, rickettsia, bacteria, protozoa);
- antiproliferative activity;
- antitumorigenic and antimutagenic effects;
- antitoxic action;
- radioprotective effect;
- stimulates macrophages and enhances phagocytosis;
- enhances the cytotoxic effect of sensitised lymphocytes on target cells;
- increases the formation of surface antigens;
- enhances or inhibits the activity of many cellular enzymes;
- enhances the cytotoxic effect of double-stranded RNA
- suppresses or enhances the production of antibodies;
- activates natural killer cells;
- stimulates the release of histamine by basophils;
- increases the synthesis of prostaglandins;
- enhances the formation of histocompatibility antigens;
- suppresses delayed-type hypersensitivity.
Bacillus subtilis and Bacillus licheniformis bacteria as constituents of healthy microflora
To clarify, Bacillus subtilis bacteria and Bacillus licheniformis are not normal flora in microbial communities of humans and animals. In other words, they possess properties that enable the body to maintain microbicides at ecologically natural levels. Those properties optimise metabolism. They also supply the organism with biologically active and building substances, ensuring qualitative digestion of food. These species of bacteria come from the environment and enter the gastrointestinal tract (GIT) and the skin in physical conditions. Currently, more than 3000 species of these bacteria are known.
Bacteria Bacillus subtilis and Bacillus licheniformis live in the digestive tract after entering for no more than 30 days, and after that, they leave the body naturally. This species of bacteria does not die in the stomach because it is highly resistant to gastric juice's effects in spore form.
Effect
They transform into vegetative forms in the mouth and the small and large parts of the intestine. These bacteria also multiply there and produce biologically active substances in the environment. They also affect the growth and development of putrefactive, pathogenic, opportunistic microflora, such as E. coli. Moreover, other microorganisms restore the normal functioning of the microflora of the gastrointestinal tract.
The ability to suppress the growth and development of the microflora of the above types of bacteria is mainly due to the production of polyene antibiotics like bacitracin and licheniformins. These antibiotics also indirectly optimise the functioning of the human and animal immune systems.
Irrigation of the intestine in our London clinic helps normalise the colon's microflora. In doing that, we also prepare the best environment for probiotics. It may also help restore the body's immune system properties.
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