Bacillus subtilis and Bacillus licheniformis bacteria in the human intestine

The bacteria Bacillus subtilis and Bacillus licheniformis were initially found in the soil in an ecologically clean region of Siberia. The new strains were derived by way of modifying them with plasmid pBMB 105, which are capable of producing interferon 2-alpha-leukocyte human. In the human body, this type of interferon is produced by leukocytes and lymphoblasts during the viral infection or in response to induction by synthetic polyribonucleotides. Being a factor of nonspecific resistance of the body, it plays a controlling and regulatory role in maintaining the homeostasis in the human body and has the following main activities:

• antiviral effect;
• suppresses the growth and development of intracellular infectious agents of a non-viral nature (chlamydia, rickettsia, bacteria, protozoa);
• antiproliferative activity;
• antitumorigenic and antimutagenic effect;
• antitoxic action;
• radioprotective effect;
• stimulates macrophages and enhances phagocytosis;
• enhances the cytotoxic effect of sensitised lymphocytes on target cells;
• increases the formation of surface antigens;
• enhances or inhibits the activity of many cellular enzymes;
• enhances the cytotoxic effect of double-stranded RNA
• suppresses or enhances the production of antibodies;
• activates natural killer cells;
• stimulates the release of histamine by basophils;
• increases the synthesis of prostaglandins;
• enhances the formation of histocompatibility antigens;
• suppresses delayed-type hypersensitivity.

Bacillus subtilis and Bacillus licheniformis bacteria as constituents of healthy microflora.

Bacillus subtilis bacteria and Bacillus licheniformis are not normal flora in microbial communities of humans and animals, but they possess properties that enable the body to maintain microbicides at the level of ecologically natural, optimise the metabolism and supply the organism with biologically active and building substances, ensure qualitative digestion of food. In the physical conditions, the bacteria of these species have always come from the environment into the gastrointestinal tract (GIT), the skin and its damaged areas, the mucous membranes of humans and animals with the dust when eating plant foods or drinking water. Currently, more than 3000 species of these bacteria are known.

Bacteria Bacillus subtilis and Bacillus licheniformis after entering the digestive tract live in it for no more than 30 days, and after that, they leave the body naturally. In the stomach, the bacteria of this species does not die, because it is highly resistant to the effects of gastric juice in spore form.

In the mouth and the thin and thick parts of the intestine, they transformed into a vegetative form, multiply and produce biologically active substances into the environment. It affects on the growth and development of putrefactive, pathogenic and opportunistic microflora, the number of populations of lacto- and bifidobacteria, E. coli and other microorganisms restore providing the normal functioning of the microflora of the gastrointestinal tract.

The ability to suppress the growth and development of microflora of the above types of bacterias is made mainly by their abilities to produce polyene antibiotics – bacitracin and licheniformins. Suppression is carried out by the direct antagonism concerning infectious agents and indirectly through the optimisation of the functioning of human and animal immune system.

Irrigation of the intestine in our clinic in London helps to normalise the microflora of the colon and restore its immune system properties.