The disease is attended with excess development of fatty tissues. The disease usually develops after reaching 40 years of age. It is typical of women. Adiposity primarily results from an energy balance disturbance, i.e. discrepancy between the amount of energy entering the organism and its consumption. Adiposity often arises from hyperalimentation. It can also result from impaired control over energy consumption. The disease may be prompted by hereditary-constitutional predisposition, insufficient physical activity, some physiological states (pregnancy, lactation, climax, etc.), and such factors as age, sex and professional occupation. Adiposity is a hypothalamo-hypophyseal disease. Its pathogenesis centres on expressed hypothalamic disturbances causing changes in behavioural reactions (particularly, food behaviour) and hormonal disturbances. The activity of the hypothalamo-hypophyseal-adrenal system is increased. The adrenocorticotrophic hormone secretion rises. The hydrocortisone production speed is increased. Metabolism is accelerated. The secretion of the somatotropic hormone featuring lipolytic effect is reduced.
The secretion of gonadotropin and sexual steroids is impaired. It is characterised by hypersulinemia whose efficiency is decreased. The metabolism of thyroid hormones and sensitivity of peripheral tissues are impaired. Adiposity can be alimentary-constitutional, hypothalamic and endocrine. Alimentary-constitutional adiposity is of family-type and, as a rule, affects the members of one family or their blood relatives. It is caused by regular hyperalimentation, improper nutrition, lack of physical exercise, etc. Hypothalamic adiposity arises from a disturbance of the hypothalamic functions and features a number of peculiar clinic characteristics. Endocrine adiposity is one of the first symptoms of a primary pathology of the endocrine glands, i.e. hypercorticoidism, hypothyroidism, hypogonadism, etc. However, all the forms lead to certain hypothalamic disturbances, either primary, or developing in the course of the disease progress.