Toxic diffuse goitre (Graves’-Basedow’s disease) indicates the thyroid gland’s hyperplasia and hyperfunction. Hereditary factors, infections, intoxications, psychemical traumas, etc., may also prompt that condition.
The foundation of pathogenesis is a disturbance of immune “supervision”, resulting in the formation of autoantibodies. They are a stimulating factor causing the gland’s hyperfunction, hyperplasia, and hypertrophy. To clarify, of significance here is the change in the sensitivity of tissues to thyroid hormones, leading to a disturbance of metabolism between them.
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The surplus of thyroid hormones affects different kinds of metabolism, organs and tissues. So, patients complain of irritability, weepiness, hyperrealism, insomnia, flaccidity, fatigue, sweating and hand and body tremors. Patients lose weight despite good appetite (limos). Young patients, on the contrary, may gain weight (“fat” Basedow). Furthermore, the thyroid gland can diffusely enlarge. However, there is no relationship between its enlargement and the seriousness of thyrotoxicosis.
Changes in the eyes are as follows:
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