As is known, the intestinal microbiota (microflora) depends quantitatively and qualitatively on many factors:
Since obesity affects the intestines, let’s figure it out.
Vanessa Ridaura and her colleagues conducted a fascinating experiment. They obtained samples of intestinal microflora in four pairs of human twins (in which one of each pair was slim, and the other one was obese). These samples were injected into sterile-grown mice (there were no microorganisms in the intestine of these rodents) and watched the animals gain weight. They fed mice with fodder, rich in fibre and with a standard percentage of fat.
An ordinary mouse and a mouse suffering from obesity.
It turned out that those mice that received the microflora of lean people retained a standard percentage of fat in the body in a few weeks, and those that got the intestinal microflora of fat people started gaining weight (although they were fed on low-fat food). When the mice of both groups were placed in one cage after infection, and they began to exchange microflora (the mice sometimes eat faeces), the microbiota of the lean “defeated” the fatty microbiota: both groups of mice remained slim.
Based on the results of these experiments, we can assume how obesity affects the gut. In the body, there is still a population of bacteria responsible for obesity, and a population responsible for reducing body weight. The intake of fatty and low-fibre foods contributes to changes in intestinal microflora towards an increase of those bacteria that contribute to excess weight.
Of course, it is incorrect to say that dysbiosis is the only cause of obesity, as it is a pluricausal process. However, it can lead to metabolic disturbances in the body along with other predisposing genetic, environmental and social factors. Obesity occurs when the intake and formation of energy exceed body needs, and the balance of unused resources is deposited in adipose tissue.
What is one of the primary sources of energy in the body?
This is glucose, of course. The results of the experiment revealed that the composition of the intestinal microflora in mice with elevated blood glucose (diabetes mellitus) is similar to the formation of intestinal microflora of obese mice. Hence, these processes are closely related.
Now we know how obesity affects the intestines. Colonic irrigation with the probiotic implant can restore the intestinal microflora and strengthen its muscles, which will reduce the risk of obesity and help in dealing with it.