The decisive role of normal microflora of the human intestine is excellent. Providing antigenic irritation of the mucous membrane the intestinal autoflora stimulates the maturation of mechanisms of general and local immunity. In the process of its vital activity, lactic, acetic, formic, propionic, butyric acids are formed, which promote acidification of the chyme and prevent the propagation of pathogenic and opportunistic bacteria in the intestine. Synthesized by intestinal autoflora antibiotic substances (colicin, lactolin, streptocid, nisin, lysozyme) have a bactericidal or bacteriostatic effect on pathogens.
The composition of the microflora in the biofilm of the intestine can vary under the influence of various factors. If these factors, affecting the fixation directly or indirectly, survival and functioning of healthy intestinal microflora, exceed the mechanisms of body defence, they provoke the development of intestinal dysbiosis. To restore it, proper correction of the intestinal microflora is necessary.
Antibiotics have the most pronounced adverse effect on the normal intestinal microflora. Microbiological disorders occur in the prescription of adsorbing, laxatives, expectorants, choleretic drugs. These groups of drugs when administered internally change the motility of the gastrointestinal tract, disrupt the formation of mucus, contribute to the development of an imbalance in the healthy microflora. In newborns and infants, a violation of the intestinal microbiocenosis may be due to factors such as the aggravated course of pregnancy, childbirth, and infanticide.
The spectrum of clinical syndromes and various diseases associated with intestinal dysbiosis is now quite broad and tends to increase. Here are some of them: diarrhoea, constipation, colitis, malabsorption syndrome, hypertension, raised cholesterol level in the blood, urolithic and cholelithiasis, atopic dermatitis, bronchial asthma, liver pathology, malignant neoplasms.
Correction of the intestinal microflora sets the main tasks for itself: