The decisive role of correction of intestinal microflora of the human intestine is excellent. By providing antigenic irritation of the mucous membrane, the intestinal autoflora stimulates the maturation of mechanisms of general as well as local immunity.
In the process of its vital activity, flora generates lactic, acetic, formic, propionic as well as butyric acids. They promote acidification of the chyme. They also prevent the propagation of pathogenic as well as opportunistic bacteria in the intestine. Intestinal autoflora synthesises antibiotic substances such as colicin, lactolin, streptocid, nisin, lysozyme. Besides, they have a bactericidal or bacteriostatic effect on pathogens.
Nevertheless, the composition of the microflora in the biofilm of the intestine can vary under the influence of various factors. If these factors, affecting the fixation directly or indirectly, survival and functioning of healthy intestinal microflora, exceed the mechanisms of body defence, then they provoke the development of intestinal dysbiosis. So, to restore it, proper correction of intestinal microflora is necessary.
Thus, antibiotics have the most pronounced adverse effect on healthy intestinal microflora. Furthermore, microbiological disorders occur in the prescription of adsorbing, laxatives, expectorants, choleretic drugs. These groups of medicines, when administered internally change the motility of the gastrointestinal tract, disrupting the formation of mucus, contribute to the development of an imbalance in the healthy microflora. In newborns and infants, a violation of the intestinal microbiocenosis may be due to factors such as the aggravated course of pregnancy, childbirth, and infanticide.
The spectrum of clinical syndromes and various diseases associated with intestinal dysbiosis is now quite broad. Besides, it tends to increase. Here are some of them:
Correction of intestinal microflora sets the main tasks for itself: