Candida albicans is a constituent of the microscopic flora of the human organism. In the early 20s, candidiasis occurred rather rarely, but in the 40s, with the use of antibiotics, it became far more frequent, and the number of cases has steadily been going up since. Now Candida is the most widespread pathogen of opportunistic mycosis. It may cause mucous and cutaneous lesions and systemic diseases as well. Generally, candidiasis has an endogenic origin. And, it results from dysmetabolic disorders and dysfunctions of the immune system.
There are over 150 species of mycosis pathogens. C. Albicans cause over 90% of lesions. Any dysfunctions of immunocompetent cells or normal microbial cenosis initiate the disease. Babies are infected when passing through the parturient canal or during breastfeeding. Urogenital candidiasis is transmitted sexually. Cutaneous injuries, increased perspiration and maceration promote candidiasis development.
The microbial cenosis disturbance causes excessive growth of Candida Albicans due to the disproportional use of broad-spectrum antibiotics or a change in the surrounding microflora composition. Metabolic or hormonal disorders such as diabetes mellitus, pregnancy and peroral contraceptive administration also promote candidiasis. Besides, immunodeficiency or the use of immunodepressants (such as glucocorticoids) can cause speedy forms of chronic candidiasis. Further, it will be affecting the skin or mucosa.
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Surface candidiasis develops where high temperatures and dampness are present (for example, in skin folds). It also emerges because of cutaneous maceration resulting from repeated contact with water. The manifestations of candidiasis intertrigo are an erythematous rash or a vesicular-pustular rash with signs of maceration (generally around skin folds with children) which leads to erosion. Besides, most often, mucocutaneous candidiasis emerges in a cavity or the vagina.
The disease develops with metabolic disorders in the background or with abnormal microbial cenosis. Also, candidiasis of the mouth (mycotic stomatitis) is typical of treating with broad-spectrum antibiotics. It can also indicate immunodeficiency conditions. So, the characteristic manifestations are white and yellowish agmina on the mucosal surface. The lesions commonly combine with diffuse erythema as well as extremely dry mucosa.
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The vulvovaginitis caused by Candida Albicans is very common with women who take perorative or intrauterine contraceptives. Those in their last trimester of pregnancy (the condition accounted for by the immunodepressive effect of factor associated with serum alpha-globulin) may experience the same. Disseminated candidiasis is a result of an invasion of pseudohyphae into parenchymatous organs. And that results in microabscesses in those organs with an occasional granulomatous inflammatory reaction. Cases without medication end up fatally.
Deep mycosis develops as a result of
Dissemination of surface candidiasis occurs quite rarely. Most common are lesions of kidneys, eyes, encephalon and heart. Multiple nidi are mostly revealed in the case of continuous contamination, for example, through a catheter.