Anatori Sealife Comments 0 25th April 2012

Candida albicans is a constituent of the microscopic flora of the human organism. In the early 20s candidiasis occurred rather rarely but in the 40s, with the use of antibiotics it became far more frequent and the number of cases has steadily been going up since. Now Candida is the most widespread pathogens of opportunistic mycosis. It may cause mucous and cutaneous lesions and systemic diseases as well. Generally candidiasis has endogenic origin, it results from dysmetabolic disorders and dysfunctions of the immune system. There are over 150 species of mycosis pathogens. Over 90% lesions are caused by C. albicans. Any dysfunctions of immunocompetent cells or normal microbial cenosis initiate the disease. Babies are infected when passing through the parturient canal or during breastfeeding. Urogenital candidiasis is transmitted sexually. Cutaneous injuries, increased perspiration and maceration promote candidiasis development. Excessive growth of C. albicans is caused by the microbial cenosis disturbance as a result of the disproportional use of broad-spectrum antibiotics or a change in the surrounding microflora composition. Metabolic or hormonal disorders such as diabetes mellitus, pregnancy and peroral contraceptive administration also promote candidiasis. Immunodeficiency or the use of immunodepressant (such as glucocorticoids) can cause speedy forms or chronic candidiasis affecting the skin or mucosa. Surface candidiasis develops where high temperatures and dampness are present (for example in skin folds) or where there is cutaneous maceration resulting from a repeated contact with water. The manifestations of candidiasis intertrigo are an erythematous rash or a vesicular-pustular rash with signs of maceration (generally around skin folds with children) which leads to erosion. Most often mucocutaneous candidiasis emerges in a cavity or in the vagina. The disease develops with metabolic disorders in the background or with abnormal microbial cenosis. Candidiasis of mouth (mycotic stomatitis) is a typical consequence of treating with broad-spectrum antibiotics and of immunodeficiency conditions. The typical manifestations are white and yellowish agmina on the mucosal surface. The lesions are often combined with diffuse erythema and extremely dry mucosa. The vulvovaginitis caused by C. albicans is very common with women who take perorative or intrauterine contraceptives or are in their last trimester of pregnancy (the condition accounted for by the immunodepressive effect of factor associated with serum alpha-globulin). Disseminated candidiasis is a result of invasion of pseudohyphae into parenchymatous organs, which results in microabscesses in those organs with an occasional granulomatous inflammatory reaction. Cases without medication end up fatally. Deep mycosis develops as a result of organ transplantation, heart surgery, long-term venous catheterization, prosthetic implantation, overeating, long-term glucocorticoid or immunodepressant administration. Dissemination of surface candidiasis occurs quite rarely. Most common are lesions of kidneys, eyes, encephalon and heart. Multiple nidi are mostly revealed in the case of continuous contamination, for example through a catheter.

Will cancer cells be defeated by sodium bicarbonate?  —   Author: Hongtao Zhang — Department of Pathology and Laboratory Medicine University of Pennsylvania Philadelphia USA